Had a medication review this morning and we talked about how things keep reoccurring, these periods of time where the depression seems worse, and I'm unable to deal with things as well.  Apparently a body doesn't really build an immunity or tolerance to a medication but it is possible that it won't have the desired effect.  We agreed I would try a new anti-depressant, one that works two ways on the depression rather than one, and I would go back in 6 weeks or so to see how I'm doing.  It's not that I think drugs are the answer but I am willing to try other things if it helps me (and my mood) remain more neutral than negative/depressed.